Dovenia Ponnoth, Ph.D.

Dovenia Ponnoth PhD

Dovenia Ponnoth, Ph.D.
Associate Dean and Associate Professor of Pharmacology
Biomedical Sciences 
 

Office: A311 Main Building
Phone: 304-647-6297
Fax: 304-793-6884
 

Education and Training

Postdoctoral Research Associate
West Virginia University, School of Medicine, Morgantown WV
Field: Vascular Pharmacology

ORISE Fellow, National Institute for Occupational Safety & Health (NIOSH), Morgantown WV
Field: Lung Toxicology

Doctor of Philosophy
West Virginia University School of Pharmacy, Morgantown WV
Field: Pharmaceutical and Pharmacological Sciences

Bachelor of Science
University of Mumbai, Mumbai India
Field: Pharmacy

Research Interests

My main research focus is cardiopulmonary pharmacology and the interaction between reactive airway diseases and development of cardiovascular diseases. My lab is currently studying asthma pathogenesis and the role of angiotensin ll in subsequent cardiovascular outcomes. The goal is to identify signaling mechanisms involved in cardiovascular dysfunction and develop drug therapies based on the identified targets. 

Current Lab Members

  1. Praveena Prasad (MS student)
  2. Parth Naik (MS student)
  3. Rahil Shah (MS student)
  4. Vianny Soto (Technician)

Awards and Honors

  • 2016 American Society for Pharmacology and Experimental Therapeutics (ASPET) Pharmacology Educator Award
  • 2013 Third place (poster presentation), Appalachian Translational Research Network (ATRN) Health Summit, Columbus, OH
  • 2013 Young Scientist Travel Award, Awarded by the American Society for Pharmacology and Experimental Therapeutics (ASPET) at Experimental Biology, Boston MA, April 2013
  • 2013 Post-doctoral Travel Award: Awarded by the Health Sciences Center, West Virginia University for Experimental Biology, Boston, April 2013

Selected Publications

  1. Patel M, Narke D, Kurade M, Frey KM, Siddiquee A, Mustafa SJ, Ledent C, Ponnoth DS “Limonene-induced activation of A2A adenosine receptors reduces airway inflammation and reactivity in a mouse model of asthma” (accepted 2020 Purinergic Signalling)
  2. Patel M, Kurade M, Rajalingam S, Bhavsar R, Mustafa SJ, Ponnoth DS “Role of Angiotensin II type 1 (AT1) and type 2 (AT2) receptors in airway reactivity and inflammation in an allergic mouse model of asthma” Immunopharmacol Immunotoxicol. Immunopharmacol Immunotoxicol. 2019 Jun;41(3):428-437. doi: 10.1080/08923973.2019.1609026. Epub 2019 May 7.PMID:31062639
  3. Siddiquee A, Patel M, Rajalingam S, Narke D, Kurade M, Ponnoth DS “Effect of omega-3 fatty acid supplementation on resolvin (RvE1)-mediated suppression of inflammation in a mouse model of asthma” Immunopharmacol Immunotoxicol. 2019 Mar 8:1-8. doi: 10.1080/08923973.2019.1584903. (Epub ahead of print) PMID:30849257
  4. Siddiquee A, Narke D, Kurade M, Dholakia K, Ponnoth DS “Apelin increases airway reactivity and inflammation in a mouse model of asthma” Mod Appl Bioequiv Availab 2018 3(3):555615 doi: 10.19080/MABB.2018.03.555615.
  5. Joshi A, Joshi A, Patel H, Ponnoth D, Stagni G. Cutaneous Penetration-Enhancing Effect of Menthol: Calcium Involvement  J Pharm Sci. 2017 Jul;106(7):1923-1932. doi: 10.1016/j.xphs.2017.03.041. Epub 2017 Apr 8 PMID:28400197
  6. Zaccone, E.J., Thompson, J.A., Ponnoth, D.S., Cumpston, A.M., Goldsmith,W.T., Jackson, M.C., Frazer, D.G., Hubbs, A.F., Shimko, M. and Fedan, J.S. “Popcorn flavoring effects on reactivity of rat airways in vivo and in vitro” J Toxicol Environ Health A. 2013;76(11):669-89. doi: 10.1080/15287394.2013.796302. PMID: 23941636
  7. Kunduri S, Mustafa S, Ponnoth D, Dick G, Nayeem M. “Adenosine A1 receptors link to smooth muscle contraction via CYP4a, PKC-α, and ERK1/2.” J Cardiovasc Pharmacol. 2013 Jul;62(1):78-83. doi: 10.1097/FJC.0b013e3182919591. PMID: 23519140
  8. Ponnoth DS, Nayeem MA, Tilley SL, Ledent C, Mustafa SJ “Cyp-epoxygenases contribute to A2A receptor-mediated aortic relaxation via sarcolemmal KATP channels.” Am J Physiol Regul Integr Comp Physiol. 2012 Nov; 303(10):R1003-10 doi:10.1152/ajpregu.00335.2012. Epub 2012 Sep 26.PMID: 23019210
  9. Ponnoth DS, Nayeem MA, Kunduri SS, Tilley SL, Zeldin DC, Ledent C,  Mustafa SJ “Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A receptor knockout mice” Am J Physiol Regul Integr Comp Physiol. 2012 Feb 15;302(4):R400-8. doi: 10.1152/ajpregu.00481.2011. Epub 2011 Dec 7. PMID:22160543
  10. Ponnoth DS, Mustafa SJ “Adenosine receptors and vascular inflammation” BiochimBiophys Acta. 2011 May;1808(5):1429-34. Epub 2010 Sep 9. Review.PMID:20832387
  11. Nayeem MA, Zeldin DC, Boegehold MA, Morisseau C, Marowsky A, Ponnoth DS, Roush KP, Falck JR “Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase” Am J Physiol Regul Integr Comp Physiol. 2010 Jul;299(1):R325-33. Epub 2010 Apr 28 PMID:20427718
  12. Ponnoth DS, Nadeem A, Tilley S, Mustafa SJ “Involvement of A1 adenosine receptors in altered vascular responses and inflammation in an allergic mouse model of asthma” Am J Physiol Heart Circ Physiol. 2010 Jul;299(1):H81-7. Epub 2010 Apr 16 PMID:20400685
  13. Ponnoth DS, Sanjani MS, Ledent C, Roush K, Krahn T, Mustafa SJ “Absence of adenosine-mediated aortic relaxation in A(2A) adenosine receptor knockout mice” Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1655-60. Epub 2009 Sep 11. PMID:19749167
  14. Nadeem A, Ponnoth DS, Ansari HR, Batchelor TP, Dey RD, Ledent C, Mustafa SJ "A2A AR deficiency leads to impaired tracheal relaxation via NADPH oxidase pathway in allergic mice" J Pharmacol Exp Ther. 2009 Jul;330(1):99-108. Epub 2009 Apr 24. PMID:19395654