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Joyce Morris-Wiman, Ph.D.

Joyce Morris-Wiman, Ph.D.
Associate Professor of Neuroscience
Biomedical Sciences

Email: jmorriswiman@osteo.wvsom.edu
Office: A321
Phone: (304) 793-6857
Fax: (304) 793-6884

 

Education / Training

Ph.D, University of Michigan, Ann Arbor, MI

Postdoctoral training, University of Michigan, Ann Arbor, MI

Research Interests

At present the laboratory is pursuing three projects:

  1. Glial response in a jaw muscle pain model The central hypothesis of this project is that glial cell activation after a unilateral repetitive acidic saline injection into the masseter muscle is part of a cascade of events that elicit gender-specific, bilateral primary afferent neuron neuroplastic changes in the trigeminal system and result in persistent jaw muscle pain.
     
  2. Role of glial senescence in aging of the mouse brain Previous studies have established that alterations in the number and phenotype of astrocytes and microglia correlate with loss of function associated with aging in the hippocampus and hypothalamus. The central hypothesis of this project is that the activity of glia is altered with aging and glia no longer provide for neuronal maintenance.
     
  3. Role of cytokines/chemokines in muscle repair. Previous studies have determined that masseter lacks the capacity to repair effectively in response to injury. The goals of this project are to examine the different responses of TA and masseter to in vitro conditions to determine if the deficit lies in the muscle or in the

Lab Members

Garrett Clemons (Research Technician)

Joanna Wieckowski, OMS-2

Jerry Henderson, OMS-2

Kathleen Woods, OMS-2

 

Selected Scholarly Activity

Bonadio, J., Saunders, T., Tsai, E., Goldstein, S., Morris-Wiman, J., Brinkley, L., Dolan, D., Altschuler, R., Hawkins, J.Jr, Bateman, J., Mascara, T. and Jaenisch, R. (1990) Transgenic mouse model of the mild dominant form of osteogenesis imperfecta. PNAS (USA) 87:7145-7149.

Morris-Wiman, J., Sego, R., Brinkley, L. and Dolce, C. (2000) The effects of sialoadenectomy and exogenous EGF on taste bud morphology and maintenance. Chemical Senses 25:9-19.

Morris-Wiman, J., Brinkley, L., and Sego, R. (2000) An In Vitro Model for the Study of Taste Papillae Morphogenesis Using Branchial Arch Explants. Brain Res. Protocols 5 (2):153-158.

Morris-Wiman, J., Burch, H. and Basco, E. (2000) Temporospatial distribution of matrix metalloproteinases and tissue inhibitors of metalloproteinases during murine secondary palate morphogenesis. Anat. Embryol. 202: 129-141

C.G. Widmer, Morris-Wiman, J. and Nekula, C. (2002) Spatial distribution of myosin heavy chain isoforms in mouse masseter. J. Dent. Res. 81 (1): 33-38

C. Dolce, Vakani, A., Archer, L., Morris-Wiman, J. and Holliday, L.S. (2003) Effects of Echistatin and an RGD peptide on orthodontic tooth movement. J. Dent Res. 82 (90: 682-686.

Widmer, C.G., English, A.W. and Morris-Wiman, J. (2007) Developmental and functional considerations of masseter muscle partitioning, Arch Oral Biol., 52:305-308.

C.G. Widmer, Morris-Wiman, J. and Nekula, C. (2002) Spatial distribution of myosin heavy chain isoforms in mouse masseter. J. Dent. Res. 81 (1): 33-38 C.

Dolce, Vakani, A., Archer, L., Morris-Wiman, J. and Holliday, L.S. (2003) Effects of Echistatin and an RGD peptide on orthodontic tooth movement. J. Dent Res. 82 (90: 682-686.

Widmer, C.G., English, A.W. and Morris-Wiman, J. (2007) Developmental and functional considerations of masseter muscle partitioning, Arch Oral Biol., 52:305-308.

Widmer, C.G. and Morris-Wiman, J. (2010) Limb, Respiratory and Masticatory Muscle Compartmentalization: Developmental and Hormonal Considerations, Progress in Brain Research, 187:63-80

Widmer, C., Nguyen, V.D., Chiang, H. and Morris-Wiman, J. (2012) Increased vertical dimension effects on masseter muscle fiber phenotype during maturation. Angle Orthodontist. http://dx.doi.org/10.2319/122111-786.1

Widmer, C.G. and Morris-Wiman, J. (2015) Assessment of Incising Ethology in the Absence and Presence of Jaw Muscle Pain in a Mouse Home Cage Environment, Physiology and Behavior, 149:229-38. http://dx.doi: 10.1016/j.physbeh.2015.06.015.

Recent Conference Abstracts

Morris-Wiman, J. Harris, A. and Widmer, C.G. (2010) An altered inflammatory response is associated with delayed repair in masseter. FASEB Summer Research Conference-Skeletal Muscle Satellite and Stem Cells. July 18-23rd

Widmer, CG and Morris-Wiman, J. (2011) Behaviors associated with a mild\moderate orofacial pain model, Soc. Neurosci, 174.13

Morris-Wiman, J. and Widmer, CG. (2012) Persistent masticatory muscle pain correlates with distinct cytokine/chemokine expression profiles. Soc. Neurosci, 83.03

C.G. Widmer and J. Morris-Wiman (2013) Incising behavior during mild-moderate masticatory muscle pain in mice, Soc. Neurosci. 782.05/MMM28

J. Morris-Wiman and C.G. Widmer (2013) Behavioral assessment of incising in mice, Soc. Neurosci. 782.06/MMM29 C. Ballam, B. Mensinki, and J. Morris-Wiman. (2013) Investigation of the role of TGFβ in satellite activation and differentiation in vitro. 2013 POSTER SESSION AND STUDENT POSTER COMPETITION 57TH AOA ANNUAL RESEARCH CONFERENCE

B. Mensink, C. Ballam, M. Mattox, and J. Morris-Wiman. (2013) Astrocyte ALDH1L1 and GFAP Expression in the Brainstem of Young and Aged Mice. 2013 POSTER SESSION AND STUDENT POSTER COMPETITION 57TH AOA ANNUAL RESEARCH CONFERENCE

C.G. Widmer and J. Morris-Wiman (2014) Non-Invasive, In Vivo Assessment of the Modulating Effect of Persistent Pain on the Output of the Central Pattern Generator for Mastication. Soc. Neurosc.239.22.

C.G. Widmer and J. Morris-Wiman (2015) In vivo assessment of changes in mandibular incising force direction in the absence and presence of persistent jaw muscle pain. Soc. Neurosc.421.

J. Morris-Wiman and C.G. Widmer (2015) The effect of persistent jaw closing muscle pain on incising force output parameters. Soc. Neurosc.421