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Kristie Grove Bridges, Ph.D.

Kristie Grove Bridges, Ph.D.
Professor and Chair
Biomedical Sciences

Office: A337
Email: kbridges@osteo.wvsom.edu
Fax: (304) 793-6884

 

Education / Training

BS, Biology and Chemistry, Bucknell University

PhD, Pharmacology, Yale University

Postdoctoral training, Harvard Medical School, Department of Biological Chemistry and Molecular Pharmacology

Research Interests

My lab focuses on investigating the relationship between uric acid metabolism and insulin resistance.  We are also involved in clinical studies aimed at characterizing cardiometabolic abnormalities associated with pediatric obesity and how they impact future disease development.

Selected Scholarly Activity

Fox, C., Bernardino, L., Cochran, J., Essig, M. and Bridges, K.G.  Inappropriate use of homeostasis model assessment cutoff values for diagnosing insulin resistance in pediatric studies.  J Am Osteopath Assoc., 117(11): 689-696, 2017.

Bridges, K.G., Jarrett, T., Thorpe, A., Baus, A. and Cochran, J.  Use of the triglyceride to HDL cholesterol ratio for assessing insulin sensitivity in overweight and obese children in rural Appalachia, Journal of Pediatric Endocrinology and Metabolism. 29 (2): 153-156, 2016.

Soukup M., Biesiada I., Henderson A., Idowu B., Rodeback D., Ridpath L., Bridges E.G., Nazar A.M., Bridges K.G. Salivary uric acid as a noninvasive biomarker of metabolic syndrome. Diabetol Metab Syndr. 4(1):14, 2012.

Dillon M.C., Opris D.C., Kopanczyk R., Lickliter J., Cornwell H.N., Bridges E.G., Nazar A.M., Bridges K.G. Detection of homocysteine and C-reactive protein in the saliva of healthy adults: comparison with blood levels. Biomark Insights, 5: 57-61, 2010.

Henderson, A.T., Fisher, J. F., Blair, J., Shea, C., Li, T.S. and Bridges, K.G.  Effects of Rib Raising on the Autonomic Nervous System:  A Pilot Study Using Noninvasive Biomarkers.  J Am Osteopath Assoc., 110: 324-30, 2010.

Bridges, K.G., Chopra, R., Lin, L., Svenson, K., Tam, A., Jin, G., Cowling, R., Lovering, F., Akopian, T.N., Diblasio-Smith, E., Annis-Freeman, B., Marvell, T.H., LaVallie, E.R., Zollner, R.S., Bard, J., Somers, W.S., Stahl, M.L. and Kriz, R.  A novel approach to identifying beta-secretase inhibitors: Bis-statine peptide mimetics discovered using structure and spot synthesis.  Peptides, 27: 1877-1885, 2006.

Hoffhines, A.J., Damoc, E., Bridges, K.G., Leary, J.A. and Moore, K.L.  Detection and purification of tyrosine-sulfated proteins using a novel anti-sulfotyrosine monoclonal antibody,  J. Biol. Chem., 281:37877-37887, 2006.

Lovering, F., Angell, Y., Zhang, Y-L. and Bridges, K.  Development of a polyvalent assay system for lead identification.  Bioorg. Med. Chem. Lett., 14:  5081-5083, 2004.

Hu, B., Fan, K. Y., Bridges, K., Chopra, R., Lovering, F., Cole, D., Zhou, P., Ellingboe, J., Jin, G., Cowling, R. and Bard, J.  Synthesis and SAR of bis-statine based peptides as BACE 1 inhibitors.  Bioorg. Med. Chem. Lett., 14:  3457-3460, 2004.

Bridges, K.G., Chow, C.S., Coen, D.M.  Identification of crucial hydrogen-bonding residues for the interaction of herpes simplex virus DNA polymerase subunits via peptide display, mutational, and calorimetric approaches. J. Virol., 75: 4990-4998, 2001.  

Bridges, K.G., Hua, Q., Brigham-Burke, M.R., Martin, J.D., Hensley, P., Dahl, C.E., Digard, P., Weiss, M.A., and Coen, D.M.   Secondary structure and structure-activity relationships of peptides corresponding to the subunit interface of herpes simplex virus DNA polymerase.  J. Biol. Chem., 275: 472-478, 2000.

Chen, S-H., Cook, W.J., Grove, K.L. and Coen, D.M. Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant.  J. Virol., 72: 6710-6715, 1998.

Zhu, Y-L., Pai, S.B., Liu, S-H., Grove, K.L., Jones, B.C., Simons, C., Zemlicka, J. and Cheng, Y-C.  Inhibition of replication of hepatitis B virus by Cytallene in vitro.  Antimicrob. Agents Chemother., 41: 1755-1760, 1997.

Grove, K.L., Guo, X., Kukhanova, M., Chu, C. K. and Cheng, Y-C. Beta-L-(-)-dioxolane cytidine (beta-L-(-)-OddC) as a potent compound for the treatment of cancer.  Nucleosides and Nucleotides, 16: 1229-1233, 1997.

Liu, S-H., Grove, K.L. and Cheng, Y-C. Unique metabolism of a novel antiviral L-nucleoside analog, L-FMAU: A substrate for both thymidine kinase and deoxycytidine kinase. Antimicrob. Agents Chemother., 42: 833-839, 1997

Grove, K.L. and Cheng, Y-C.  Uptake and metabolism of the new anticancer compound beta-L-(-)-dioxolane cytidine in human prostate carcinoma DU-145 cells. Cancer Res., 56: 4187-4191, 1996. 

Grove, K.L., Guo, X., Liu, S-H., Gao, Z., Chu, C.K. and Cheng, Y-C. Anticancer activity of beta-L-(-)-dioxolane cytidine, a novel nucleoside analog with the unnatural beta-L-configuration. Cancer Res., 55: 3008-3011, 1995.