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Carolyn Komar

Carolyn Komar
Associate Professor
Biomedical Sciences

Office: A327
Phone: (304) 647-6345
Fax: (304) 645-4859
Email: ckomar@osteo.wvsom.edu

 

Education / Training

Undergraduate B.S. University of Vermont

M. S. University of Connecticut

Ph.D. Cornell University

Postdoctoral training University of Kentucky

Research Interests

My research interests focus on how the metabolic status of women affects their reproductive health. To this end, I have been involved in various projects investigating how endogenous products of metabolism, as well as exogenous compounds, impact ovarian gene expression, steroidogenesis, etc.

Other areas of research in which I am engaged are the structure/function relationship of the reproductive tract to the ovarian cycle, and improving methods to monitor bone mineral density.

The information gained from our studies will enable us to better identify what goes awry leading to female sub-/infertility, understand pathologies effecting fertility such as polycystic ovary syndrome, and how changes associated with aging impact women's health.

Book Chapters

Komar, C. M. and Long, M. J. (2013) Immunohistochemical techniques to identify and localize proteins of interest in paraffin-embedded tissue sections.  In: Methods in Molecular Biology: Peroxisome Proliferator-Activated Receptors. Badr, M. Z. & Youseff, J. (eds).  Humana Press, New York.  2013. Pp 197-206  

Fortune, J. E., Rivera, G. M. and Komar, C. M. (2001) Selection and differentiation of dominant ovarian follicles in cattle.  In: BR Monographs of Reproduction & Catalog Group 2001, A.A.M. Rosa e Silva (ed.).  Editora Arte & Ciencia (Villipress), Sao Paulo, Brazil, pg. 21-38.

Curry Jr., T. E., Komar, C. M., Burns, P. D. and Nothnick, W. B.  (2000) Periovulatory changes in ovarian metalloproteinases and tissue inhibitors of metalloproteinases (TIMPs) following indomethacin treatment.  In: Ovulation: Evolving Scientific and Clinical Concepts, E. Y. Adashi (ed.).  Springer Verlag, New York.  pp 265-276

Fortune, J. E., Voss, A. K., Chandrasekher, Y. A., Berndtson, A. K., Komar, C. M. and Tabb, J. S.  (2000) Oxytocin: Periovulatory production and effects.  In: Ovulation: Evolving Scientific and Clinical Concepts, E. Y. Adashi (ed.).  Springer Verlag, New York.  pp 154-166 

Publications Peer Reviewed

White, Matthew, Jarrett, Traci, Komar, Carolyn.  (2016) Correlation between digit length ratios and risk factors associated with metabolic syndrome.  Submitted to Preventative Med-Reports.

Long, Mary J., Sairam, Ram M., Komar, Carolyn M.  (2009) Initiation of the Expression of Peroxisome Proliferator - Activated Receptor gamma (PPARγ) in the Rat Ovary and the Role of Follicle Stimulating Hormone (FSH).  Reproductive Biology & Endocrinology.  7: 145. 

Komar, Carolyn M., Zacharachis-Jutz, France, Cretekos, Chris J., Behringer, Richard R. Rasweiler IV, John J. (2007) Polarized Ovaries of the Bat - Glossophaga soricina: A Novel Model for Studying Ovarian Development, Folliculogenesis and Ovulation.  The Anatomical Record.  290 (11): 1439-1448.

Komar Carolyn M.  (2007) The Importance of Comparative Physiology: A focus on ovarian biology and the role of animal models.  Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources.  2 (25): 12.

Tinfo, Nicole and Komar, Carolyn M.  (2007) A role for peroxisome proliferator-activated receptor γ in cell survival, not steroid production, in luteal tissue from the rat.  Reproduction.  133(1): 187-196.

Bridges, P. J., Komar, C. M., and Fortune, J. E.  (2006) Gonadotropin-induced expression of mRNA for cyclooxygenase-2 (COX-2) and secretion of prostaglandins E and F2α in bovine preovulatory follicles is regulated by the progesterone receptor.  Endocrinology.  147(10): 4713-4722.

Banerjee, J., Long, M. J. and Komar, C. M.  (2006) Effects of LH on PPARγ in the rat ovary before and after the gonadotropin surge. Reproduction. 131:93-101.

Komar, C. M.  (2005) Peroxisome proliferator-activated receptors (PPARs) and ovarian function - implications for regulating steroidogenesis, differentiation, and tissue remodeling.  Reproductive Biology and Endocrinology.  31: 41.

Madan, P., Bridges, P. J. , Komar, C. M., Beristain, A. G., Rajamahendran, R., Fortune, J. E. and MacCalman, C. D.  (2003) Expression of messenger ribonucleic acid for ADAMTS subtypes changes in the periovulatory follicle after the gonadotropin surge and during luteal development and regression in cattle.  Biology of Reproduction.  69: 1506-1514.

Komar, Carolyn M. and Curry Jr., Thomas E.  (2003) Inverse relationship between the expression of messenger ribonucleic acid for peroxisome proliferator-activated receptor g and P450 side chain cleavage in the rat ovary.  Biology of Reproduction. 69:549-555.

Simpson K. S., Komar, C. M., Curry Jr., T. E.  (2003) Localization and Expression of Tissue Inhibitor of Metalloproteinase-4 (TIMP-4) in the Immature Gonadotropin-Stimulated and Adult Rat Ovary. Biology of Reproduction.  68: 214-221

Jo, M., Komar, C. M. and Fortune, J. E.  (2002) Gonadotropin surge induces two separate increases in messenger RNA for progesterone receptor in bovine periovulatory follicles.  Biology of Reproduction.  67(6): 1981-1988

Komar, C. M. and Curry Jr., T. E. (2002) Localization and expression of mRNAs for the peroxisome proliferator-activated receptors in ovarian tissue from naturally cycling and pseudopregnant rats.  Biology of Reproduction.  66:1531-1539.

Komar, C. M., Braissant, O., Wahli, W., and Curry Jr., T. E. (2001) Expression and localization of peroxisome proliferator-activated receptors in the rat ovary during follicular development and the periovulatory period.  Endocrinology.  142(11): 4831-4838.

Komar, C. M., Berndtson, A. K., Evans, A. C. O. and Fortune, J. E.  (2001) The decline in circulating estradiol during the periovulatory period is correlated with decreases in estradiol and   androgen, and in messenger ribonucleic acid for P450 aromatase and P450 17a-hydroxylase,          in bovine preovulatory follicles.  Biology of Reproduction.  64: 1797-1805.

Komar, C. M., Matousek, M., Mitsube, K., Mikuni, M., Brannstrom, M., and Curry Jr., T. E.  (2001) Effects of genistein on the periovulatory expression of messenger ribonucleic acid for matrix metalloproteinases and tissue inhibitors of metalloproteinases in the rat ovary.  Reproduction.  121: 259-265.

Cooke, R. G., Nothnick, W. B., Komar, C., Burns, P. and Curry Jr., T. E.  (1999) Collagenase and gelatinase messenger ribonucleic acid expression and activity during follicular development in the rat ovary.  Biology of Reproduction.  61: 1309-1316.

Evans, A. C. O., Komar, C. M., Wandji, S-A. and Fortune, J. E. (1997) Changes in androgen secretion and luteinizing hormone pulse amplitude are associated with the recruitment and growth of ovarian follicles during the luteal phase of the bovine estrous cycle.  Biology of Reproduction.  57: 394-401.

Invited Talks

Heilongjiang University of Chinese Medicine, Harbin, China (2006) Title: Peroxisome proliferator-activated receptors in the ovary: implications for involvement in polycystic ovary syndrome.

Des Moines University Osteopathic Medical Center, Des Moines, IA (2005) Title: The peroxisome proliferator-activated receptors involvement in regulating ovarian function.

USDA MARC, Clay Center, NE (2004) Title: Regulation and potential roles of peroxisome proliferator-activated receptor γ in the ovary.

Department of Animal Science, University of Connecticut, Storrs, CT (2003) Title: The regulation and potential roles of peroxisome proliferator activated receptors in the ovary.

Department of Physiology, Medical College of Georgia, Athens, GA (2003) Title: Peroxisome proliferator-activated receptors in the ovary: location and potential functions.

NC-220 Annual Meeting, Ames, IA (2002) The potential role of peroxisome proliferator-activated receptors in reproduction.

Department of Animal Science, Iowa State University, Ames Iowa (2001) Title: Evidence that peroxisome proliferator-activated receptors play a role in ovarian function.

Department of Biology, University of Northern Iowa, Cedar Falls, Iowa (2001) Title: Peroxisome proliferator-activated receptors - Are they involved in ovarian function?

Kentucky Histotechnology Society, Lexington, KY (2000) Title: Utilizing histological analysis to understand the cyclic changes that occur in the mammalian ovary.